N-alkylaminoacids and their derivatives interact with melanocortin receptors

Felikss Mutulis; Ilze Mutule; Jarl E S Wikberg

doi:10.1016/s0960-894x(02)00089-6

N-alkylaminoacids and their derivatives interact with melanocortin receptors

Bioorg Med Chem Lett. 2002 Apr 8;12(7):1039-42. doi: 10.1016/s0960-894x(02)00089-6.

Authors

Felikss Mutulis¹, Ilze Mutule, Jarl E S Wikberg

Affiliation

¹ Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala Biomedical Center, PO Box 591, Uppsala University, S-751 24 Uppsala, Sweden.

PMID: 11909712
DOI: 10.1016/s0960-894x(02)00089-6

Abstract

Thirty four N-alkylaminoacids (Arg, Trp, Nal, Pro, Hyp, L and D) and derivatives were prepared by a process that included reductive alkylation of the amino function. Both solid phase and solution synthesis was used. Title substances displayed binding activity on melanocortin receptors MC(1,3-5) reaching the low micromolar range.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkylation
Amino Acids / metabolism*
Binding, Competitive
Cell Line
Humans
Iodine Radioisotopes
Models, Chemical
Molecular Structure
Oxidation-Reduction
Protein Binding
Receptor, Melanocortin, Type 3
Receptor, Melanocortin, Type 4
Receptors, Corticotropin / metabolism*
Receptors, Melanocortin

Substances

Amino Acids
Iodine Radioisotopes
Receptor, Melanocortin, Type 3
Receptor, Melanocortin, Type 4
Receptors, Corticotropin
Receptors, Melanocortin
melanocortin 5 receptor